04053cam a2200469Ma 4500001002800000003000900028005001700037006001900054007001500073008004100088020001500129020001500144020001800159020001800177020001500195020001800210035002100228040001300249050002500262082001400287245012500301250001200426260006900438300005600507500007200563500007100635504007900706505057400785505059601359505059501955506009102550520065302641538002903294650002303323650001603346650002903362650002203391655002203413700002303435700002703458856009803485 AALScienceDirectebook000011 BD-DhAAL 20191205132802.0 m o d cr cn||||||||| 130827s2013 ne a ob 001 0 eng d a0128022299 a0444626557 a9780128022290 a9780444626554 z044462645X z9780444626455 a(OCoLC)859158730 aBD-DhAAL 4 aRA1211 b.A383 2013eb 04 a615.9 223 00 aAdvances in molecular toxicology nVolume 7 / cedited by James C. Fishbein, Jacqueline M. Heilman. h[electronic resource] a1st ed. aAmsterdam, Netherlands ; aOxford, England : bElsevier, c�2013. a1 online resource (xii, 241 pages) : billustrations aOff-Campus Access: Athens ID and Password Required aOn-Campus Access: No User ID or Password Required aIncluded bibliographical references at the end of each chapters and index. 0 aFront Cover; Advances in Molecular Toxicology; Copyright; Contents; Contributors; Preface; Chapter One: AHR- and ER-Mediated Toxicology and Chemoprevention; 1. Introduction; 2. AHR Ligands; 2.1. Natural and/or dietary ligands; 2.2. Endogenous ligands; 3. Aryl Hydrocarbon Receptor; 3.1. Mechanism of AHR transactivation; 3.2. The nongenomic pathway; 3.3. Negative feedback regulation of AHR transactivation; 3.4. AHR-regulated signaling and toxicity; 3.5. Adverse human health effects of dioxin-like compounds; 3.6. Adaptive response pathway; 3.7. Developmental pathway 8 a5. PAH Metabolism to DNA-Reactive Metabolites6. Diol-Epoxide Pathway; 7. The Radical Cation Pathway; 8. Depurinating PAH Adducts and AP Sites; 9. Mutagenesis Studies to Address PAH Radical Cations; 10. Evidence for AP Site Formation Due to Radical Cations; 11. Mutagenicity Studies with B[a]P Radical Cation Products; 12. The Quinone Pathway; 13. Exposure to OPAHs; 14. Biological Relevance of OPAH; 15. Conclusion; References; Chapter Four: Nitrogen Oxides Toxicology of the Aerodigestive Tract; 1. Introduction; 2. Chemistry of Reactive Oxygen and Nitrogen Oxide Species and the Scavengers 8 a6.2. Phenylenediamine arylamine xenobiotics7. Arylamine Drugs and Blood Dyscrasias; 7.1. Procainamide; 7.2. Aminoglutethimide; 7.3. Aminopyrine; 8. Diverting Toxic Arylamine Free Radical Generation to Detoxification: Importance of Free Radical Targets; 9. Mixtures Toxicology-Application to Arylamine Free Radicals; 10. Protein Radicals and Toxicity-Future Prospects; 11. Closing Remarks; References; Chapter Three: Genotoxicity of Polycyclic Aromatic Hydrocarbon Metabolites: Radical Cations and Ketones; 1. Introduction; 2. Exposure to PAHs; 3. Exposure Risks of PAH; 4. DNA Damage by PAH aElectronic access restricted to authorized BRAC University faculty, staff and students aAdvances in Molecular Toxicology features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment and produced by the human body manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. aMode of access: Internet 0 aMolecular biology. 0 aToxicology. 7 aMolecular biology. 2fast 7 aToxicology. 2fast 4 aElectronic books. 1 aFishbein, James C. 1 aHeilman, Jacqueline M. 40 zFull text available on ScienceDirect uhttp://www.sciencedirect.com/science/book/9780128022290