05380pam a2200553 i 4500999001700000001002800017003000900045005001700054006001900071007001500090008004100105016001400146016002000160020001500180020001800195020001500213020001800228035009600246040001300342050002500355060001500380060001000395072002500405082001400430100004100444245012000485260004300605300005600648500007200704500007100776504005100847505059400898505059201492505056902084505060402653505015503257506009103412520078703503538002904290650002904319650004304348650003504391650002904426655002904455776014004484856009804624942001304722952009104735 c41955 d41955 AALScienceDirectebook000010 BD-DhAAL 20191205135502.0 m o d cr mn||||||||| 150326t20152015enka ob 001 0 eng d 7 a101664503 7 a101664503 2DNLM a0128014911 a9780128014912 z0128014113 z9780128014110 a(OCoLC)905649781 z(OCoLC)908042071 z(OCoLC)1066453312 z(OCoLC)1105178086 z(OCoLC)1105559539 aBD-DhAAL 4 aRM301.5 b.T46 2015eb 00 a2015 G-769 10 aQV 38 7 aMED x071000 2bisacsh 04 a615.7 223 0 aLoftsson, Thorsteinn eauthor. 938053 10 aEssential pharmacokinetics : ba primer for pharmaceutical scientists / cThorsteinn Loftsson. h[electronic resource] 1 aAmsterdam ; aBoston : bElsevier, c2015 a1 online resource (vii, 170 pages) : billustrations aOff-Campus Access: Athens ID and Password Required aOn-Campus Access: No User ID or Password Required aIncludes bibliographical references and index. 0 aFront Cover; Essential Pharmacokinetics; Copyright Page; Contents; Preface; 1 Introduction; 1.1 Some Basic Concepts; 1.2 Pharmacokinetic Models; 1.3 Population Pharmacokinetics; References; 2 Basic Concepts of Pharmacokinetics; 2.1 One-Compartment Open Model; 2.1.1 IV Bolus Injection; 2.1.2 IV Infusion; 2.2 Two-Compartment Open Model; 2.2.1 IV Bolus Injection; 2.2.2 IV Infusion; 2.3 Three-Compartment Open Model; 2.4 Pharmacokinetics of Drug Absorption; 2.4.1 One-Compartment Open Model with Zero-Order Drug Absorption; 2.4.2 One-Compartment Open Model with First-Order Drug Absorption. 8 a2.10 Drug Permeation Through Biomembranes and Drug Transporters2.10.1 Biomembranes; 2.10.2 Passive Transport Through Mucosa; References; 3 Physicochemical Properties and Pharmacokinetics; 3.1 Lipinski's Rule of Five; 3.2 The Biopharmaceutics Classification System; 3.3 The Biopharmaceutics Drug Disposition Classification System; 3.4 Metabolizability, Soft Drugs, and Prodrugs; 3.5 Pharmacokinetics of Excipients; References; 4 Drug Pharmacokinetics After Alternative Routes of Administration; 4.1 Fentanyl Transdermal Patch; 4.2 Estradiol Sublingual Tablets; 4.3 Diazepam Suppositories. 8 a2.4.3 One-Compartment Open Model with Urine Sample Collection2.4.4 Two-Compartment Open Model with First-Order Drug Absorption; 2.4.5 Flip-Flop Pharmacokinetics; 2.5 Bioavailability; 2.6 Drug Distribution, Protein Binding, and Clearance; 2.6.1 Protein Binding; 2.6.2 Clearance; 2.7 Multiple-Dose Regimens; 2.7.1 Multiple-Dosage by IV Bolus Injection and One-Compartment Open Model; 2.7.2 Multiple-Dosage by Oral Administration and One-Compartment Open Model; 2.7.3 Loading Dose; 2.8 Nonlinear Pharmacokinetics; 2.8.1 Michaelis-Menten Equation; 2.9 Drug Metabolism. 8 a4.4 Midazolam Nasal Spray4.5 Pulmonary Delivery (Inhalation) and Subcutaneous Injection of Insulin; 4.6 Topical Delivery of Dexamethasone to the Eye; References; 5 Pharmacologic Response and Drug Dosage Adjustments; 5.1 Therapeutic Drug Monitoring; 5.2 Dosage Adjustments; 5.3 Pharmacodynamics; 6 The Effect of Food and Excipients on Drug Pharmacokinetics; References; 7 Practice Problems; 7.1; 7.2; 7.3; 7.4; 7.5; 7.6; 7.7; 7.8; 7.9; 7.10; 7.11; 7.12; 7.13; 7.14; 7.15; 7.16; 7.17; References; Appendix I: Answers to Problems in Chapter 7; 7.1; A; B; C; D; E; F; G; 7.2; A; B; C; 7.3; A; B; C; 7.4. 8 a7.57.6; A; B; 7.7; A; B; C; 7.8; A; B; C; 7.9; A; B; C; 7.10; 7.11; 7.12; 7.13; 7.14; 7.15; 7.16; 7.17; Appendix II: Symbols and Abbreviations; Index. aElectronic access restricted to authorized BRAC University faculty, staff and students aEssential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. aMode of access: Internet 0 aPharmacokinetics. 938054 7 aMEDICAL xPharmacology. 2bisacsh 938055 7 aPharmacokinetics. 2fast 938054 12 aPharmacokinetics. 938054 4 aElectronic books. 938058 08 iPrint version: aThorsteinn Loftsson. tEssential pharmacokinetics. dAmsterdam ; Boston : Elsevier Academic Press, �2015 z9780128014110 40 zFull text available on ScienceDirect uhttp://www.sciencedirect.com/science/book/9780128014110 2ddc cEBK 00 10 2ddc 40 70 aBRACUL bBRACUL d2019-12-05 l0 o615.7 LOF r2019-12-05 w2019-12-05 yEBK