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005			20191205132802.0
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008			130827s2013 ne a ob 001 0 eng d
020			_a0128022299
020			_a0444626557
020			_a9780128022290
020			_a9780444626554
020			_z044462645X
020			_z9780444626455
035			_a(OCoLC)859158730
040			_aBD-DhAAL
050		4	_aRA1211 _b.A383 2013eb
082	0	4	_a615.9 _223
245	0	0	_aAdvances in molecular toxicology _nVolume 7 / _cedited by James C. Fishbein, Jacqueline M. Heilman. _h[electronic resource]
250			_a1st ed.
260			_aAmsterdam, Netherlands ; _aOxford, England : _bElsevier, _c�2013.
300			_a1 online resource (xii, 241 pages) : _billustrations
500			_a<strong>Off-Campus Access:</strong> Athens ID and Password Required
500			_a<strong>On-Campus Access:</strong> No User ID or Password Required
504			_aIncluded bibliographical references at the end of each chapters and index.
505	0		_aFront Cover; Advances in Molecular Toxicology; Copyright; Contents; Contributors; Preface; Chapter One: AHR- and ER-Mediated Toxicology and Chemoprevention; 1. Introduction; 2. AHR Ligands; 2.1. Natural and/or dietary ligands; 2.2. Endogenous ligands; 3. Aryl Hydrocarbon Receptor; 3.1. Mechanism of AHR transactivation; 3.2. The nongenomic pathway; 3.3. Negative feedback regulation of AHR transactivation; 3.4. AHR-regulated signaling and toxicity; 3.5. Adverse human health effects of dioxin-like compounds; 3.6. Adaptive response pathway; 3.7. Developmental pathway
505	8		_a5. PAH Metabolism to DNA-Reactive Metabolites6. Diol-Epoxide Pathway; 7. The Radical Cation Pathway; 8. Depurinating PAH Adducts and AP Sites; 9. Mutagenesis Studies to Address PAH Radical Cations; 10. Evidence for AP Site Formation Due to Radical Cations; 11. Mutagenicity Studies with B[a]P Radical Cation Products; 12. The Quinone Pathway; 13. Exposure to OPAHs; 14. Biological Relevance of OPAH; 15. Conclusion; References; Chapter Four: Nitrogen Oxides Toxicology of the Aerodigestive Tract; 1. Introduction; 2. Chemistry of Reactive Oxygen and Nitrogen Oxide Species and the Scavengers
505	8		_a6.2. Phenylenediamine arylamine xenobiotics7. Arylamine Drugs and Blood Dyscrasias; 7.1. Procainamide; 7.2. Aminoglutethimide; 7.3. Aminopyrine; 8. Diverting Toxic Arylamine Free Radical Generation to Detoxification: Importance of Free Radical Targets; 9. Mixtures Toxicology-Application to Arylamine Free Radicals; 10. Protein Radicals and Toxicity-Future Prospects; 11. Closing Remarks; References; Chapter Three: Genotoxicity of Polycyclic Aromatic Hydrocarbon Metabolites: Radical Cations and Ketones; 1. Introduction; 2. Exposure to PAHs; 3. Exposure Risks of PAH; 4. DNA Damage by PAH
506			_aElectronic access restricted to authorized BRAC University faculty, staff and students
520			_aAdvances in Molecular Toxicology features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment and produced by the human body manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.
538			_aMode of access: Internet
650		0	_aMolecular biology. _937974
650		0	_aToxicology. _937975
650		7	_aMolecular biology. _2fast _937974
650		7	_aToxicology. _2fast _937975
655		4	_aElectronic books. _937976
700	1		_aFishbein, James C. _937977
700	1		_aHeilman, Jacqueline M. _937978
856	4	0	_zFull text available on ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780128022290
942			_2ddc _cEBK