In silico drug designing against Klebsiella pneumoniae adhesin protein
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019.
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| Idioma: | English |
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Brac University
2019
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| Acesso em linha: | http://hdl.handle.net/10361/12084 |
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10361-120842019-09-30T05:40:00Z In silico drug designing against Klebsiella pneumoniae adhesin protein Hoq, Muntasirul Islam, Dr. Aparna Mubassir, M H M Department of Mathematics and Natural Sciences, Brac University Klebsiella pneumoniae Capsular polysaccharide This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019. Cataloged from PDF version of thesis. Includes bibliographical references (page 29-36). Klebsiella pneumoniae, is one of the causative agents of many nosocomial infections. In spite of having a plethora of information on the virulent factors of this bacteria, no definite vaccines have yet been designed or developed in order to prevent the infections caused by the multidrug resistant pathogen. Hence, taking this in account, the present study designed an in silico peptide vaccine against K. pneumoniae, by predicting both B-cell and T-cell epitopes which is followed by molecular docking. In this study, peptide sequences of Type 1 fimbrial adhesin protein of 28 strains of K. pneumoniae were retrieved and then tested by in silico methods to identify the conserved antigenic portions, present in all the 28 strains of the pathogen. VTLQRGSAY and IYDSRTDKPW were found to be the most potential T-cell and B-cell epitope, among all the other antigenic portions. Furthermore, the T-cell epitope VTLQRGSAY, when docked with HLA-A protein, fitted perfectly inside the groove of it. These results prove that the designed epitopes could be a potent candidate for vaccine development against K. pneumoniae. Muntasirul Hoq B. Biotechnology 2019-05-22T08:22:01Z 2019-05-22T08:22:01Z 2019 2019-01 Thesis ID 15136024 http://hdl.handle.net/10361/12084 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 36 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Klebsiella pneumoniae Capsular polysaccharide |
| spellingShingle |
Klebsiella pneumoniae Capsular polysaccharide Hoq, Muntasirul In silico drug designing against Klebsiella pneumoniae adhesin protein |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2019. |
| author2 |
Islam, Dr. Aparna |
| author_facet |
Islam, Dr. Aparna Hoq, Muntasirul |
| format |
Thesis |
| author |
Hoq, Muntasirul |
| author_sort |
Hoq, Muntasirul |
| title |
In silico drug designing against Klebsiella pneumoniae adhesin protein |
| title_short |
In silico drug designing against Klebsiella pneumoniae adhesin protein |
| title_full |
In silico drug designing against Klebsiella pneumoniae adhesin protein |
| title_fullStr |
In silico drug designing against Klebsiella pneumoniae adhesin protein |
| title_full_unstemmed |
In silico drug designing against Klebsiella pneumoniae adhesin protein |
| title_sort |
in silico drug designing against klebsiella pneumoniae adhesin protein |
| publisher |
Brac University |
| publishDate |
2019 |
| url |
http://hdl.handle.net/10361/12084 |
| work_keys_str_mv |
AT hoqmuntasirul insilicodrugdesigningagainstklebsiellapneumoniaeadhesinprotein |
| _version_ |
1814309109394046976 |