Applicability of Lipinski‟s rule of five in drugs used in the treatment of cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021.
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Brac University
2022
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10361-166052022-05-16T21:01:42Z Applicability of Lipinski‟s rule of five in drugs used in the treatment of cancer Surovi, Snigdha Farhana Karim, Eshaba Department of Pharmacy, Brac University Intravenous Bioavailability Partition coefficient Hydrogen bond donor Hydrogen bond acceptor Malignant Drug development. Cancer -- Treatment. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. Cataloged from PDF version of thesis report. Includes bibliographical references (pages 31-32). Generally, most anticancer medications are managed by an intravenous mixture. During the last decade, notwithstanding, the utilization of oral anticancer medications has expanded, on account of demonstrated adequacy and patient inclination for oral treatment. These days, most new anticancer medications are being developed are oral administration. The advancement of oral delivery is, nonetheless, frequently hampered by low and variable bioavailability influenced by physicochemical properties. The partition coefficient, molecular weight, number of Hydrogen bond donors, and number of Hydrogen bond acceptors of anticancer drugs were searched and tabulated into a Microsoft Excel spreadsheets. Drugs which do not comply with Lipinski‟s rule of five were identified. The types of their marketed dosage forms were checked. Snigdha Farhana Surovi B. Pharmacy 2022-05-16T05:00:57Z 2022-05-16T05:00:57Z 2021 2021-08 Thesis ID 16346025 http://hdl.handle.net/10361/16605 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 32 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Intravenous Bioavailability Partition coefficient Hydrogen bond donor Hydrogen bond acceptor Malignant Drug development. Cancer -- Treatment. |
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Intravenous Bioavailability Partition coefficient Hydrogen bond donor Hydrogen bond acceptor Malignant Drug development. Cancer -- Treatment. Surovi, Snigdha Farhana Applicability of Lipinski‟s rule of five in drugs used in the treatment of cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2021. |
| author2 |
Karim, Eshaba |
| author_facet |
Karim, Eshaba Surovi, Snigdha Farhana |
| format |
Thesis |
| author |
Surovi, Snigdha Farhana |
| author_sort |
Surovi, Snigdha Farhana |
| title |
Applicability of Lipinski‟s rule of five in drugs used in the treatment of cancer |
| title_short |
Applicability of Lipinski‟s rule of five in drugs used in the treatment of cancer |
| title_full |
Applicability of Lipinski‟s rule of five in drugs used in the treatment of cancer |
| title_fullStr |
Applicability of Lipinski‟s rule of five in drugs used in the treatment of cancer |
| title_full_unstemmed |
Applicability of Lipinski‟s rule of five in drugs used in the treatment of cancer |
| title_sort |
applicability of lipinski‟s rule of five in drugs used in the treatment of cancer |
| publisher |
Brac University |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10361/16605 |
| work_keys_str_mv |
AT surovisnigdhafarhana applicabilityoflipinskisruleoffiveindrugsusedinthetreatmentofcancer |
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1814306835381878784 |