In vitro collateral sensitivity: a potential approach against multiple antibiotic resistant bacteria
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2023.
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| Ngôn ngữ: | English |
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Brac University
2024
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| Truy cập trực tuyến: | http://hdl.handle.net/10361/22149 |
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10361-22149 |
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10361-221492024-01-15T21:02:53Z In vitro collateral sensitivity: a potential approach against multiple antibiotic resistant bacteria Yousha, Nasrat Ahmed Badhan, Sadia Islam Dina, Shatabdi Deb Ahsan, MD Jahid Hossain, M. Mahboob Ahmed, Akash Department of Mathematics and Natural Sciences, Brac University Antibiotic resistance Antibiotic susceptibility testing Antibiotic exposure Collateral sensitivity Drug resistance This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2023. Catalogued from PDF version of thesis. Includes bibliographical references (pages 62-68). Antimicrobial Resistance (AMR) has long been recognized as a major issue. With the emergence and rapid spread of antibiotic-resistant bacteria, the world's stock of viable antibiotics is rapidly depleting. In this regard, Collateral Sensitivity (CS) is a promising and alternative approach with the potential to treat bacterial infections. The project aimed to study the collateral sensitivity of gram-negative resistant bacteria by exposing clinical isolates to antibiotics in individual and combination antibiotic trials. The results were promising for both Klebsiella pneumoniae and Pseudomonas aeruginosa. The efficiency of Linezolid against gram-negative bacteria was one of novel findings of this study. Exposure to Linezolid in combination with other antibiotics produced encouraging results. 50% of the P. aureginosa strains showed susceptibility to Ceftriaxone, Levofloxacin, Tetracycline, Amikacin and Meropenem when exposed to Linezolid itself whereas 75% of the K. pneumoniae strains showed susceptibility to Tetracycline. Although the clinical implementation is still under study, the collateral sensitivity treatment could prove be an adequate addition to the current treatment to lower the antibiotic resistance ratio. Further research at the molecular level is suggested to better understand the effect of collateral sensitivity. Nasrat Ahmed Yousha Sadia Islam Badhan Shatabdi Deb Dina MD Jahid Ahsan B. Biotechnology 2024-01-15T05:01:25Z 2024-01-15T05:01:25Z 2023 2023-07 Thesis ID 19136020 ID 19136030 ID 19136009 ID 19326021 http://hdl.handle.net/10361/22149 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 68 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Antibiotic resistance Antibiotic susceptibility testing Antibiotic exposure Collateral sensitivity Drug resistance |
| spellingShingle |
Antibiotic resistance Antibiotic susceptibility testing Antibiotic exposure Collateral sensitivity Drug resistance Yousha, Nasrat Ahmed Badhan, Sadia Islam Dina, Shatabdi Deb Ahsan, MD Jahid In vitro collateral sensitivity: a potential approach against multiple antibiotic resistant bacteria |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology 2023. |
| author2 |
Hossain, M. Mahboob |
| author_facet |
Hossain, M. Mahboob Yousha, Nasrat Ahmed Badhan, Sadia Islam Dina, Shatabdi Deb Ahsan, MD Jahid |
| format |
Thesis |
| author |
Yousha, Nasrat Ahmed Badhan, Sadia Islam Dina, Shatabdi Deb Ahsan, MD Jahid |
| author_sort |
Yousha, Nasrat Ahmed |
| title |
In vitro collateral sensitivity: a potential approach against multiple antibiotic resistant bacteria |
| title_short |
In vitro collateral sensitivity: a potential approach against multiple antibiotic resistant bacteria |
| title_full |
In vitro collateral sensitivity: a potential approach against multiple antibiotic resistant bacteria |
| title_fullStr |
In vitro collateral sensitivity: a potential approach against multiple antibiotic resistant bacteria |
| title_full_unstemmed |
In vitro collateral sensitivity: a potential approach against multiple antibiotic resistant bacteria |
| title_sort |
in vitro collateral sensitivity: a potential approach against multiple antibiotic resistant bacteria |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/22149 |
| work_keys_str_mv |
AT youshanasratahmed invitrocollateralsensitivityapotentialapproachagainstmultipleantibioticresistantbacteria AT badhansadiaislam invitrocollateralsensitivityapotentialapproachagainstmultipleantibioticresistantbacteria AT dinashatabdideb invitrocollateralsensitivityapotentialapproachagainstmultipleantibioticresistantbacteria AT ahsanmdjahid invitrocollateralsensitivityapotentialapproachagainstmultipleantibioticresistantbacteria |
| _version_ |
1814308496722624512 |