A review on regulation of autophagy by microRNA in human breast cancer
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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Brac University
2024
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| Rochtain ar líne: | http://hdl.handle.net/10361/23101 |
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10361-231012024-06-04T21:04:40Z A review on regulation of autophagy by microRNA in human breast cancer Ritu, Fariha Akhter Sharmin, Sabrina School of Pharmacy, Brac University Tumor suppressor Endogenous MicroRNA Transcriptional gene expression Dysregulation Radiotherapy Chemotherapy Malignacy Cytosolic organelles Cancer research. Human physiology. Cell physiology. This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from PDF version of thesis. Includes bibliographical references (pages 40-41). A conserved catabolic process called autophagy involves the recycling of cytosolic organelles or components via a lysosome-dependent pathway. A number of disorders, such as Alzheimer's disease, Parkinson's disease, and cancer, are linked to abnormalities in autophagy. According to the current theory, autophagy appears to act as a tumor suppressor during the early stages of the development of cancer, but as the disease progresses, autophagy may promote and/or assist the growth and spread of the tumor as well as make it more resistant to treatment. Autophagy is therefore regarded as a stagedependent dual player in cancer. Endogenous non-coding short RNAs called microRNAs (miRNAs) control posttranscriptional gene expression in a negative manner.Additionally, mounting evidence from the literature suggests that dysregulation of miRNA expression affects how cancer forms, invades, metastasizes, and responds to chemotherapy or radiotherapy. As a result, research on autophagy-regulating miRNA in cancer will aid in the creation of new disease indicators and therapeutic approaches as well as a better understanding of malignancies given the significance of autophagy for cancer biology. Several of these cancer-related miRNAs may be studied since they have a role in controlling autophagy. We will concentrate on autophagy, miRNA, risk factors, cancer diagnosis, and cancer treatment in this review. Fariha Akhter Ritu B. Pharmacy 2024-06-04T03:27:14Z 2024-06-04T03:27:14Z 2023 2023-04 Thesis ID 18346079 http://hdl.handle.net/10361/23101 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 41 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Tumor suppressor Endogenous MicroRNA Transcriptional gene expression Dysregulation Radiotherapy Chemotherapy Malignacy Cytosolic organelles Cancer research. Human physiology. Cell physiology. |
| spellingShingle |
Tumor suppressor Endogenous MicroRNA Transcriptional gene expression Dysregulation Radiotherapy Chemotherapy Malignacy Cytosolic organelles Cancer research. Human physiology. Cell physiology. Ritu, Fariha Akhter A review on regulation of autophagy by microRNA in human breast cancer |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Sharmin, Sabrina |
| author_facet |
Sharmin, Sabrina Ritu, Fariha Akhter |
| format |
Thesis |
| author |
Ritu, Fariha Akhter |
| author_sort |
Ritu, Fariha Akhter |
| title |
A review on regulation of autophagy by microRNA in human breast cancer |
| title_short |
A review on regulation of autophagy by microRNA in human breast cancer |
| title_full |
A review on regulation of autophagy by microRNA in human breast cancer |
| title_fullStr |
A review on regulation of autophagy by microRNA in human breast cancer |
| title_full_unstemmed |
A review on regulation of autophagy by microRNA in human breast cancer |
| title_sort |
review on regulation of autophagy by microrna in human breast cancer |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23101 |
| work_keys_str_mv |
AT ritufarihaakhter areviewonregulationofautophagybymicrornainhumanbreastcancer AT ritufarihaakhter reviewonregulationofautophagybymicrornainhumanbreastcancer |
| _version_ |
1814309385685434368 |