A pharmacovigilance study on Memantine: signal detection of Rhabdomyolysis and death

This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.

Bibliographic Details
Main Author:	Bakar, Osama Bin Abu
Other Authors:	Yasmin, Hasina
Format:	Thesis
Language:	English
Published:	Brac University 2024
Subjects:	Alzheimer’s disease Neurological disorder Dementia FAERS database FDA adverse event reporting system Rhabdomyolysis Alzheimer's disease > Therapy Nervous System Diseases
Online Access:	http://hdl.handle.net/10361/23186

id	10361-23186
record_format	dspace
spelling	10361-231862024-06-06T21:02:40Z A pharmacovigilance study on Memantine: signal detection of Rhabdomyolysis and death Bakar, Osama Bin Abu Yasmin, Hasina School of Pharmacy, Brac University Alzheimer’s disease Neurological disorder Dementia FAERS database FDA adverse event reporting system Rhabdomyolysis Alzheimer's disease--Therapy Nervous System Diseases This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 42-48). Alzheimer's Disease (AD) is a complex and common neurological disorder and dementia's leading cause. Memantine works to treat moderate to severe AD. This study focused on Food and Drug Administration Adverse Event Reporting System (FAERS) data with the purpose to determine its effect on adverse events of Death and Rhabdomyolysis based on two comparators; the whole database and drug class. To conduct this disproportionality analysis, we have incorporated ROR and 95% CI values. We figured out that memantine possesses a higher mortality benefits ratio than other drugs enlisting both the comparators; whole database and drug class with a value of (ROR = 0.68; CI 95% = 0.46–1.00; P = 0.0483) and (ROR = 0.19; CI 95% = 0.13–0.28; P <0.0001) respectively. In addition, in the cases of rhabdomyolysis, we also find out that memantine has a lower profile assigning both comparators 8.10 (4.48 to 14.67; p < 0.0001); whole database and 2.25 (1.11 to 4.54; P = 0.0241); drug class. Osama Bin Abu Bakar B. Pharmacy 2024-06-06T04:51:48Z 2024-06-06T04:51:48Z ©2023 2023-02 Thesis ID: 19146094 http://hdl.handle.net/10361/23186 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 61 pages application/pdf Brac University
institution	Brac University
collection	Institutional Repository
language	English
topic	Alzheimer’s disease Neurological disorder Dementia FAERS database FDA adverse event reporting system Rhabdomyolysis Alzheimer's disease--Therapy Nervous System Diseases
spellingShingle	Alzheimer’s disease Neurological disorder Dementia FAERS database FDA adverse event reporting system Rhabdomyolysis Alzheimer's disease--Therapy Nervous System Diseases Bakar, Osama Bin Abu A pharmacovigilance study on Memantine: signal detection of Rhabdomyolysis and death
description	This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
author2	Yasmin, Hasina
author_facet	Yasmin, Hasina Bakar, Osama Bin Abu
format	Thesis
author	Bakar, Osama Bin Abu
author_sort	Bakar, Osama Bin Abu
title	A pharmacovigilance study on Memantine: signal detection of Rhabdomyolysis and death
title_short	A pharmacovigilance study on Memantine: signal detection of Rhabdomyolysis and death
title_full	A pharmacovigilance study on Memantine: signal detection of Rhabdomyolysis and death
title_fullStr	A pharmacovigilance study on Memantine: signal detection of Rhabdomyolysis and death
title_full_unstemmed	A pharmacovigilance study on Memantine: signal detection of Rhabdomyolysis and death
title_sort	pharmacovigilance study on memantine: signal detection of rhabdomyolysis and death
publisher	Brac University
publishDate	2024
url	http://hdl.handle.net/10361/23186
work_keys_str_mv	AT bakarosamabinabu apharmacovigilancestudyonmemantinesignaldetectionofrhabdomyolysisanddeath AT bakarosamabinabu pharmacovigilancestudyonmemantinesignaldetectionofrhabdomyolysisanddeath
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A pharmacovigilance study on Memantine: signal detection of Rhabdomyolysis and death

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