A review on calcium channel blockers as an effective treatment strategy for hypertension
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
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| Idioma: | English |
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Brac University
2024
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| Acesso em linha: | http://hdl.handle.net/10361/23953 |
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10361-239532024-09-01T21:02:43Z A review on calcium channel blockers as an effective treatment strategy for hypertension Shuvo, Partho Saha Omer, Humair Bin Md. School of Pharmacy, Brac University Anti-hypertensive drugs Calcium channel CCBs DHP Hypertension--Chemotherapy Hypotensive agents Calcium--Antagonists--Therapeutic use This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. Cataloged from the PDF version of thesis. Includes bibliographical references (pages 42-48). A higher force that blood applies to artery walls is characteristic of hypertension, known as high blood pressure. Calcium channel blockers (CCBs) treat hypertension via specifically blocking voltage-gated calcium channels found in the smooth muscle cells of the arterial walls. CCBs prevent calcium ions from entering these cells which relaxes the arterial smooth muscle cells and widens the blood vessels. DHP-CCBs e.g. amlodipine and nifedipine are the most frequently suggested CCBs because they are well-tolerated, have few adverse effects, and effectively control blood pressure. Diltiazem and verapamil, two non-DHP-CCBs are alternative therapies used to treat hypertension, angina and arrhythmias and block calcium channels in the heart, causing a heart rate and contractility drop. This review article covers mechanism of action, synthesis and SARs of CCBs. It aims to assist medicinal chemists in the field of developing new antihypertensive agents through presenting recent information on producing CCBs and their synthetic techniques in the literature. Partho Saha Shuvo B. Pharmacy 2024-09-01T10:17:18Z 2024-09-01T10:17:18Z ©2023 2023-12 Thesis ID 19346003 http://hdl.handle.net/10361/23953 en Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 57 pages application/pdf Brac University |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Anti-hypertensive drugs Calcium channel CCBs DHP Hypertension--Chemotherapy Hypotensive agents Calcium--Antagonists--Therapeutic use |
| spellingShingle |
Anti-hypertensive drugs Calcium channel CCBs DHP Hypertension--Chemotherapy Hypotensive agents Calcium--Antagonists--Therapeutic use Shuvo, Partho Saha A review on calcium channel blockers as an effective treatment strategy for hypertension |
| description |
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. |
| author2 |
Omer, Humair Bin Md. |
| author_facet |
Omer, Humair Bin Md. Shuvo, Partho Saha |
| format |
Thesis |
| author |
Shuvo, Partho Saha |
| author_sort |
Shuvo, Partho Saha |
| title |
A review on calcium channel blockers as an effective treatment strategy for hypertension |
| title_short |
A review on calcium channel blockers as an effective treatment strategy for hypertension |
| title_full |
A review on calcium channel blockers as an effective treatment strategy for hypertension |
| title_fullStr |
A review on calcium channel blockers as an effective treatment strategy for hypertension |
| title_full_unstemmed |
A review on calcium channel blockers as an effective treatment strategy for hypertension |
| title_sort |
review on calcium channel blockers as an effective treatment strategy for hypertension |
| publisher |
Brac University |
| publishDate |
2024 |
| url |
http://hdl.handle.net/10361/23953 |
| work_keys_str_mv |
AT shuvoparthosaha areviewoncalciumchannelblockersasaneffectivetreatmentstrategyforhypertension AT shuvoparthosaha reviewoncalciumchannelblockersasaneffectivetreatmentstrategyforhypertension |
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