Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice
This article was published in International Journal of Cancer Research [© 2011 Academic Journals Inc.] and the definite version is available at : http://scialert.net/qredirect.php?doi=ijcr.2011.254.262&linkid=pdf
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© 2011 Academic Journals Inc.
2016
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| Online adgang: | http://hdl.handle.net/10361/7121 http://doi.org/10.3923/ijcr.2011.254.262 |
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10361-71212016-12-06T10:28:09Z Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice Zahan, Ronok Alam, Md. Badrul Islam, Saiful S. Chowdhury, Nargis B. Hosain, Salman Mosaddik, Ashik Jesmin, Mele Haq, M. Ekramul Department of Pharmacy, BRAC University Alangium salvifolium Anticancer Ehrlich ascites carcinoma Hematological profile Mean survival time This article was published in International Journal of Cancer Research [© 2011 Academic Journals Inc.] and the definite version is available at : http://scialert.net/qredirect.php?doi=ijcr.2011.254.262&linkid=pdf The research study was conducted to determine the antitumor effect of the flower of Alangium salvifolium (crude extract and diethylether fractions) against Ehrlich Ascites Carcinoma (EAC) in mice at the doses of 10 mg kg-1 body weight intraperitoneally. Extract/fractions was administered for nine consecutive days. Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. Significant (p<0.001) increases of survival times 30±0.96 and 25±0.40 days for crude extract and diethylether fraction of the A. salvifolium (10 mg kg-1) treated tumor bearing mice, respectively were confirmed with respect to the control group (20±0.13 days). The extract/fraction also decreased the body weight of the EAC tumor bearing mice. Hematological studies reveal that the heamoglobin (Hb) content was decreased in EAC treated mice whereas restoration to near normal levels was observed in extract treated animals. There was a significant (p<0.001) decrease in RBC count and increase in WBC counts in extract/fraction treated animals when compared to EAC treated animals. From the result it was showed that the extract has significant anticancer activity and that is comparable to that of Bleomycin. Published 2016-12-06T06:33:27Z 2016-12-06T06:33:27Z 2011-03 Article Zahan, R., Badrul Alam, M., Saiful Islam, M., Sarker, G. C., Chowdhury, N. S., Hosain, S. B., . . . Ekramul Haque, M. (2011). Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice. International Journal of Cancer Research, 7(3), 254-262. doi:10.3923/ijcr.2011.254.262 18119727 http://hdl.handle.net/10361/7121 http://doi.org/10.3923/ijcr.2011.254.262 en http://scialert.net/qredirect.php?doi=ijcr.2011.254.262&linkid=pdf © 2011 Academic Journals Inc. |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Alangium salvifolium Anticancer Ehrlich ascites carcinoma Hematological profile Mean survival time |
| spellingShingle |
Alangium salvifolium Anticancer Ehrlich ascites carcinoma Hematological profile Mean survival time Zahan, Ronok Alam, Md. Badrul Islam, Saiful S. Chowdhury, Nargis B. Hosain, Salman Mosaddik, Ashik Jesmin, Mele Haq, M. Ekramul Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice |
| description |
This article was published in International Journal of Cancer Research [© 2011 Academic Journals Inc.] and the definite version is available at : http://scialert.net/qredirect.php?doi=ijcr.2011.254.262&linkid=pdf |
| author2 |
Department of Pharmacy, BRAC University |
| author_facet |
Department of Pharmacy, BRAC University Zahan, Ronok Alam, Md. Badrul Islam, Saiful S. Chowdhury, Nargis B. Hosain, Salman Mosaddik, Ashik Jesmin, Mele Haq, M. Ekramul |
| format |
Article |
| author |
Zahan, Ronok Alam, Md. Badrul Islam, Saiful S. Chowdhury, Nargis B. Hosain, Salman Mosaddik, Ashik Jesmin, Mele Haq, M. Ekramul |
| author_sort |
Zahan, Ronok |
| title |
Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice |
| title_short |
Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice |
| title_full |
Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice |
| title_fullStr |
Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice |
| title_full_unstemmed |
Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice |
| title_sort |
anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice |
| publisher |
© 2011 Academic Journals Inc. |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/7121 http://doi.org/10.3923/ijcr.2011.254.262 |
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