Designing novel antibacterials: application of omics science
This article was published in Klimik Dergisi [ © 2013 Klimik Dergisi ] and the definite version is available at : http://doi.org/10.5152/kd.2013.02. The Journal's website is at: http://klimikdergisi.org/eng/makale/943/83/Full-Text
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| פורמט: | Review |
| שפה: | English |
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© 2013 AVES Ibrahim Kara
2016
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| גישה מקוונת: | http://hdl.handle.net/10361/7208 http://doi.org/10.5152/kd.2013.02 |
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10361-72082016-12-12T09:54:41Z Designing novel antibacterials: application of omics science [Yeni antibiyotikler tasarlamak: "omik" bilimin uygulanmasi{dotless}] Zaman, Aubhishek M. Razzaque, Samsad Department of Mathematics and Natural Sciences, BRAC University Anti-bacterial agents Comparative genomics Omics science Structural and functional omics This article was published in Klimik Dergisi [ © 2013 Klimik Dergisi ] and the definite version is available at : http://doi.org/10.5152/kd.2013.02. The Journal's website is at: http://klimikdergisi.org/eng/makale/943/83/Full-Text Antibacterials are agents that act against pernicious bacterial pathogens by killing or inactivating them. At present, designing antibacterials have been assisted greatly by omics sciences-genomics, proteomics, metabolomics and interactomics. This review discusses different aspects of the omics sciences in simple to complex hierarchies. From the simplest of sequence analysis to more complex on the pyramid -structural, functional and interactional analysisall comprises the grand ambit of omics science. Sequence comparison can reveal novel information about drug resistance in the bacteria and thus can be of momentous significance for designing improved antibacterials. On the other hand, sequence characterization of the host protein can lead to production of effective antibiotic synthetically. Nowadays, structure based molecular designing, using computational docking techniques, has become a widely accepted routine work in drug designing processes. Moreover, new high-throughput data from microarray expression, protein-protein interaction assay are opening up a new vista for detecting more and more drug targets. Extensive focus put on to understand host-pathogen interaction on systems level has greatly accelerated the process of designing effective antibacterials against tuberculosis and many such complex diseases. Summarizing, this review exemplifies various different ways how increasingly omics science is transforming the paradigm of discovering novel antibacterials; omics approach is all set to speed up the process and bring down the expenses of the antibacterials even more in time to come. Published 2016-12-12T08:48:58Z 2016-12-12T08:48:58Z 2013 Review Zaman, A., & Razzaque, S. (2013). Designing novel antibacterials: Application of omics science. [Yeni antibiyotikler tasarlamak: "omik" bilimin uygulanmasi{dotless}] Klimik Dergisi, 26(1), 2-8. doi:10.5152/kd.2013.02 1301143X http://hdl.handle.net/10361/7208 http://doi.org/10.5152/kd.2013.02 en http://klimikdergisi.org/eng/makale/943/83/Full-Text © 2013 AVES Ibrahim Kara |
| institution |
Brac University |
| collection |
Institutional Repository |
| language |
English |
| topic |
Anti-bacterial agents Comparative genomics Omics science Structural and functional omics |
| spellingShingle |
Anti-bacterial agents Comparative genomics Omics science Structural and functional omics Zaman, Aubhishek M. Razzaque, Samsad Designing novel antibacterials: application of omics science |
| description |
This article was published in Klimik Dergisi [ © 2013 Klimik Dergisi ] and the definite version is available at : http://doi.org/10.5152/kd.2013.02. The Journal's website is at: http://klimikdergisi.org/eng/makale/943/83/Full-Text |
| author2 |
Department of Mathematics and Natural Sciences, BRAC University |
| author_facet |
Department of Mathematics and Natural Sciences, BRAC University Zaman, Aubhishek M. Razzaque, Samsad |
| format |
Review |
| author |
Zaman, Aubhishek M. Razzaque, Samsad |
| author_sort |
Zaman, Aubhishek M. |
| title |
Designing novel antibacterials: application of omics science |
| title_short |
Designing novel antibacterials: application of omics science |
| title_full |
Designing novel antibacterials: application of omics science |
| title_fullStr |
Designing novel antibacterials: application of omics science |
| title_full_unstemmed |
Designing novel antibacterials: application of omics science |
| title_sort |
designing novel antibacterials: application of omics science |
| publisher |
© 2013 AVES Ibrahim Kara |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10361/7208 http://doi.org/10.5152/kd.2013.02 |
| work_keys_str_mv |
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