04291cam a2200505Ma 4500 AALScienceDirectebook000011 BD-DhAAL 20191205132802.0 m o d cr cn||||||||| 130827s2013 ne a ob 001 0 eng d 41946 41946 0128022299 0444626557 9780128022290 9780444626554 044462645X 9780444626455 (OCoLC)859158730 BD-DhAAL RA1211 .A383 2013eb 615.9 23 Advances in molecular toxicology Volume 7 / edited by James C. Fishbein, Jacqueline M. Heilman. [electronic resource] 1st ed. Amsterdam, Netherlands ; Oxford, England : Elsevier, �2013. 1 online resource (xii, 241 pages) : illustrations <strong>Off-Campus Access:</strong> Athens ID and Password Required <strong>On-Campus Access:</strong> No User ID or Password Required Included bibliographical references at the end of each chapters and index. Front Cover; Advances in Molecular Toxicology; Copyright; Contents; Contributors; Preface; Chapter One: AHR- and ER-Mediated Toxicology and Chemoprevention; 1. Introduction; 2. AHR Ligands; 2.1. Natural and/or dietary ligands; 2.2. Endogenous ligands; 3. Aryl Hydrocarbon Receptor; 3.1. Mechanism of AHR transactivation; 3.2. The nongenomic pathway; 3.3. Negative feedback regulation of AHR transactivation; 3.4. AHR-regulated signaling and toxicity; 3.5. Adverse human health effects of dioxin-like compounds; 3.6. Adaptive response pathway; 3.7. Developmental pathway 5. PAH Metabolism to DNA-Reactive Metabolites6. Diol-Epoxide Pathway; 7. The Radical Cation Pathway; 8. Depurinating PAH Adducts and AP Sites; 9. Mutagenesis Studies to Address PAH Radical Cations; 10. Evidence for AP Site Formation Due to Radical Cations; 11. Mutagenicity Studies with B[a]P Radical Cation Products; 12. The Quinone Pathway; 13. Exposure to OPAHs; 14. Biological Relevance of OPAH; 15. Conclusion; References; Chapter Four: Nitrogen Oxides Toxicology of the Aerodigestive Tract; 1. Introduction; 2. Chemistry of Reactive Oxygen and Nitrogen Oxide Species and the Scavengers 6.2. Phenylenediamine arylamine xenobiotics7. Arylamine Drugs and Blood Dyscrasias; 7.1. Procainamide; 7.2. Aminoglutethimide; 7.3. Aminopyrine; 8. Diverting Toxic Arylamine Free Radical Generation to Detoxification: Importance of Free Radical Targets; 9. Mixtures Toxicology-Application to Arylamine Free Radicals; 10. Protein Radicals and Toxicity-Future Prospects; 11. Closing Remarks; References; Chapter Three: Genotoxicity of Polycyclic Aromatic Hydrocarbon Metabolites: Radical Cations and Ketones; 1. Introduction; 2. Exposure to PAHs; 3. Exposure Risks of PAH; 4. DNA Damage by PAH Electronic access restricted to authorized BRAC University faculty, staff and students Advances in Molecular Toxicology features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment and produced by the human body manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Mode of access: Internet Molecular biology. 37974 Toxicology. 37975 Molecular biology. fast 37974 Toxicology. fast 37975 Electronic books. 37976 Fishbein, James C. 37977 Heilman, Jacqueline M. 37978 Full text available on ScienceDirect http://www.sciencedirect.com/science/book/9780128022290 ddc EBK 0 0 ddc 0 615_900000000000000_ADV 0 67369 BRACUL BRACUL 2019-12-05 0 615.9 ADV 2019-12-05 2019-12-05 EBK