05412pam a2200553 i 4500 AALScienceDirectebook000010 BD-DhAAL 20191205135502.0 m o d cr mn||||||||| 150326t20152015enka ob 001 0 eng d 41955 41955 101664503 101664503 DNLM 0128014911 9780128014912 0128014113 9780128014110 (OCoLC)905649781 (OCoLC)908042071 (OCoLC)1066453312 (OCoLC)1105178086 (OCoLC)1105559539 BD-DhAAL RM301.5 .T46 2015eb 2015 G-769 QV 38 MED 071000 bisacsh 615.7 23 Loftsson, Thorsteinn author. 38053 Essential pharmacokinetics : a primer for pharmaceutical scientists / Thorsteinn Loftsson. [electronic resource] Amsterdam ; Boston : Elsevier, 2015 1 online resource (vii, 170 pages) : illustrations <strong>Off-Campus Access:</strong> Athens ID and Password Required <strong>On-Campus Access:</strong> No User ID or Password Required Includes bibliographical references and index. Front Cover; Essential Pharmacokinetics; Copyright Page; Contents; Preface; 1 Introduction; 1.1 Some Basic Concepts; 1.2 Pharmacokinetic Models; 1.3 Population Pharmacokinetics; References; 2 Basic Concepts of Pharmacokinetics; 2.1 One-Compartment Open Model; 2.1.1 IV Bolus Injection; 2.1.2 IV Infusion; 2.2 Two-Compartment Open Model; 2.2.1 IV Bolus Injection; 2.2.2 IV Infusion; 2.3 Three-Compartment Open Model; 2.4 Pharmacokinetics of Drug Absorption; 2.4.1 One-Compartment Open Model with Zero-Order Drug Absorption; 2.4.2 One-Compartment Open Model with First-Order Drug Absorption. 2.10 Drug Permeation Through Biomembranes and Drug Transporters2.10.1 Biomembranes; 2.10.2 Passive Transport Through Mucosa; References; 3 Physicochemical Properties and Pharmacokinetics; 3.1 Lipinski's Rule of Five; 3.2 The Biopharmaceutics Classification System; 3.3 The Biopharmaceutics Drug Disposition Classification System; 3.4 Metabolizability, Soft Drugs, and Prodrugs; 3.5 Pharmacokinetics of Excipients; References; 4 Drug Pharmacokinetics After Alternative Routes of Administration; 4.1 Fentanyl Transdermal Patch; 4.2 Estradiol Sublingual Tablets; 4.3 Diazepam Suppositories. 2.4.3 One-Compartment Open Model with Urine Sample Collection2.4.4 Two-Compartment Open Model with First-Order Drug Absorption; 2.4.5 Flip-Flop Pharmacokinetics; 2.5 Bioavailability; 2.6 Drug Distribution, Protein Binding, and Clearance; 2.6.1 Protein Binding; 2.6.2 Clearance; 2.7 Multiple-Dose Regimens; 2.7.1 Multiple-Dosage by IV Bolus Injection and One-Compartment Open Model; 2.7.2 Multiple-Dosage by Oral Administration and One-Compartment Open Model; 2.7.3 Loading Dose; 2.8 Nonlinear Pharmacokinetics; 2.8.1 Michaelis-Menten Equation; 2.9 Drug Metabolism. 4.4 Midazolam Nasal Spray4.5 Pulmonary Delivery (Inhalation) and Subcutaneous Injection of Insulin; 4.6 Topical Delivery of Dexamethasone to the Eye; References; 5 Pharmacologic Response and Drug Dosage Adjustments; 5.1 Therapeutic Drug Monitoring; 5.2 Dosage Adjustments; 5.3 Pharmacodynamics; 6 The Effect of Food and Excipients on Drug Pharmacokinetics; References; 7 Practice Problems; 7.1; 7.2; 7.3; 7.4; 7.5; 7.6; 7.7; 7.8; 7.9; 7.10; 7.11; 7.12; 7.13; 7.14; 7.15; 7.16; 7.17; References; Appendix I: Answers to Problems in Chapter 7; 7.1; A; B; C; D; E; F; G; 7.2; A; B; C; 7.3; A; B; C; 7.4. 7.57.6; A; B; 7.7; A; B; C; 7.8; A; B; C; 7.9; A; B; C; 7.10; 7.11; 7.12; 7.13; 7.14; 7.15; 7.16; 7.17; Appendix II: Symbols and Abbreviations; Index. Electronic access restricted to authorized BRAC University faculty, staff and students Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Mode of access: Internet Pharmacokinetics. 38054 MEDICAL Pharmacology. bisacsh 38055 Pharmacokinetics. fast 38054 Pharmacokinetics. 38054 Electronic books. 38058 Print version: Thorsteinn Loftsson. Essential pharmacokinetics. Amsterdam ; Boston : Elsevier Academic Press, �2015 9780128014110 Full text available on ScienceDirect http://www.sciencedirect.com/science/book/9780128014110 ddc EBK 0 0 ddc 0 615_700000000000000_LOF 0 67378 BRACUL BRACUL 2019-12-05 0 615.7 LOF 2019-12-05 2019-12-05 EBK